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Further evaluation of the differential requires exclusion of other causes of hair loss, and assessing for the typical progressive hair loss pattern of androgenic alopecia. Supplementing eunuchs with testosterone during their second decade, for example, causes slow progression of androgenic alopecia over many years, while testosterone late in life causes rapid hair loss within a month. The major site of production of IGF is the liver, although local mRNA expression at hair follicles correlates with increase in hair growth. They catalyze formation of the androgen dihydrotestosterone from testosterone, which in turn regulate hair growth. With increasing age, androgens stimulate hair growth on the face, but can suppress it at the temples and scalp vertex, a condition that has been referred to as the 'androgen paradox'. These include Grades 1, 2, 3 of balding in women based on their scalp showing in the front due to thinning of hair.
It is thought that corticotropin-releasing hormone (CRH) is the driving factor. This is a gradual shedding, with thinner and shorter hairs replacing ‘normal’ hairs. This includes amphetamines, SSRIs, ACE inhibitors, beta blockers, and hormone medications including the contraceptive pill or HRT, among others. Hair growth has four phases in a cycle. It has been found to affect up to 85% of men, and 33% of women at some point in their life.
In conclusion, androgenetic alopecia is a common, progressive form of hair loss influenced by genetics and hormones, affecting men and women differently. DHT is often blamed for androgenetic alopecia, commonly known as male or female pattern baldness. 95% of hair loss reported is caused by androgenetic alopecia with the main symptom being gradual thinning of hair. Dysbiosis—microbial imbalance—can trigger scalp inflammation, disrupt hair growth cycles, and exacerbate conditions such as seborrheic dermatitis and folliculitis, all of which can accelerate hair loss. Blood testing is essential because hormonal imbalances involving testosterone, estrogen, or DHT are a common cause of hair loss, particularly androgenetic alopecia. If you have endocrine conditions, scalp disorders, diagnosed hair loss disorders, or a strong family history of androgenetic alopecia, talk with your doctor before using any supplements.
Male and female pattern hair loss have similarities but also significant differences in their presentation and treatment. He reasoned that while hair is a common feature in most adult humans, males tend to experience hair loss more frequently than females.8 Osborn discovered that baldness follows a dominant inheritance pattern.9 Hamilton and Orentreich linked genetic predisposition, androgens and age to baldness.2,10 Its 12% Trichogen nutrient complex aims to nourish and strengthen hair follicles, promoting healthier regrowth for both men and women.
No, genetic hair loss will follow its natural timeline regardless of creatine; no evidence suggests that creatine accelerates or causes it. If your hair is changing, you need to figure out whether you are seeing androgenetic alopecia, telogen effluvium, or another condition that requires a different plan. The best current evidence suggests that creatine and hair loss do not have a cause-and-effect relationship in healthy people using standard doses. You can now cross off does creatine cause hair loss from your list of concerns. The study did not measure hair growth, hair density, follicular units, or actual hair follicle health.
They can evaluate the underlying cause of the hair loss and recommend appropriate treatment options. DHT binds to receptors in hair follicles, causing them to shrink over time, leading to thinner hair and eventually, hair loss. The impact on hair varies depending on the type of hormone therapy. Understanding the types of hormone therapy is crucial to understanding the potential impact on hair. Hormone therapy, also known as hormone replacement therapy (HRT) or endocrine therapy, is a broad term encompassing treatments that use hormones to address various medical conditions.
Various options, including lifestyle adjustments, hair care practices, and medications are available, but only 2 drugs, oral finasteride (for men) and topical minoxidil (for both men and women), are FDA-approved for AGA treatment. AGA progresses differently in males and females, with different classification scales.11 While the cause may be similar in both genders, the evidence for androgens is stronger in males and there are variations in hair loss patterns.12 However, hair thinning can start as early as puberty.3 AGA's impact on appearance and psychosocial experiences can affect the quality of life (QOL).4 Despite numerous models exploring AGA pathogenesis, there are only 2 FDA approved treatments (finasteride and minoxidil).5 Androgenetic alopecia (AGA) is the most common nonscarring alopecia and is characterised by distinct gradual patterned hair loss. With a proactive approach, including the use of a DHT blocker serum and other effective treatments, you can combat hair loss and embrace the confidence of healthy hair. As research continues to uncover the complexities of hair loss, innovative treatments and solutions are continually emerging. Your diet and overall health can significantly influence hair growth and retention.
Genetics, enzymatic activity, local scalp milieu, and lifestyle factors further sculpt the hair-loss journey. At First Point MD, we believe in empowering men with evidence-backed knowledge about hair loss. Because DHT is centrally implicated, many treatments aim to inhibit DHT formation or block its effects—while other options promote follicular health or hair regeneration. Hair growth is a complex interplay of hormones, genetics, local tissue environment, and cellular signaling. In this detailed guide, we examine the roles of testosterone, dihydrotestosterone (DHT), genetics, and treatment avenues—delivering evidence-based insights and actionable strategies. At First Point MD, we recognize that hair loss is not merely a cosmetic concern—it carries psychological impact, alters self-image, and often prompts urgency for solutions.

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